Outcomes of Population- Based Screening

Table with Results of Published Population Based Universal Screening Studies

Reference

Location

CRC patients enrolled

Selection

# LS cases diagnosed

Incidence of LS (%)

Barnetson et al.1

Scotland

870

Dx <55

38

4.4

Pinol et al.2

Spain

1222

All cases

11

0.9

Hampel et al.3,4

USA

1566

All cases

44

2.8

Cunningham et al.5

USA

257

All cases

7

2.7

Salovaara et al.6 & Aaltonen et al.7

Finland

1044

All cases

28

2.7

1Barnetson RA, Tenesa A, Farrington SM, et al. Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. N Engl J Med. 2006;354:2751-2763. [Abstract]

2Pinol V, Castells A, Andreu M, et al. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA. 2005;293:1986-1994. [Abstract]

3Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851-1860. [Abstract]

4Hampel H, Frankel WL, Martin E, et al Feasibility of screening for Lynch Syndrome among patients with colorectal cancer. J Clin Oncol. 2008;26:5783-5788. [Abstract]

5Cunningham JM, Kim CY, Christensen ER, et al. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinoma. Am J Hum Genet. 2001:69:780-790. [Abstract]

6Aaltonen, LA, Salavaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998;3389:1481-1487. [Abstract]

7Salovaara R, Loulola A, Krsito P, et al. Population –based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2000;18:2193-2200. [Abstract]