Impact of Lynch Syndrome Tumor Screening

  • A diagnosis of Lynch Syndrome may affect the patient’s
    • surgical and chemotherapeutic management decisions
    • future medical care (giving them the ability to prevent additional Lynch related cancers)
  • Identification of a patient with Lynch Syndrome also provides the opportunity for the prevention of cancer among their family members who are at high risk.
    • First-degree relatives who test negative for the identified gene mutation (pathogenic variant) are no longer at increased risk for CRC or other Lynch Syndrome-related malignancies, nor are their children at risk for Lynch Syndrome.
    • Relatives who test positive for the familial mutation require colonoscopy every one to two years beginning at age 25, in addition to screening for non-colonic cancers.

Reasons to Screen