Immunohistochemistry (IHC)

IHC testing can be performed on tumor tissue to analyze mismatch repair protein function. Tumors from individuals with Lynch syndrome are likely to demonstrate loss of mismatch repair protein expression. The pattern of loss observed can provide information about which gene is not functioning properly. As a result, IHC can be helpful both in providing information about the likelihood of Lynch syndrome and in directing testing for a germline mutation to a specific gene.

 

PowerPoint: Lynch syndrome screening with IHC